The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2007
Filed:
Jul. 22, 2004
Theresa Maria Ballard, Lutter, FR;
Silvia Gatti Mcarthur, Basel, CH;
Erwin Goetschi, Reinach, CH;
Juergen Wichmann, Steinen, DE;
Thomas Johannes Woltering, Weil am Rhein, DE;
Theresa Maria Ballard, Lutter, FR;
Silvia Gatti McArthur, Basel, CH;
Erwin Goetschi, Reinach, CH;
Juergen Wichmann, Steinen, DE;
Thomas Johannes Woltering, Weil am Rhein, DE;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to a pharmaceutical composition comprising an inhibitor of acetylcholinesterase (AChE inhibitor) and a metabotropic glutamate receptor 2 antagonist (mGluR2 antagonist) and a pharmaceutically acceptable excipient. The invention also relates to a method of treating and/or preventing acute and/or chronic neurological disorders comprising administering to a patient in need of such treatment and/or prevention a therapeutically effective amount of said AChE inhibitor and mGluR2 antagonist as well as a kit comprising said AChE inhibitor and mGluR2 antagonist. In particular, the mGluR2 antagonist relates to the compound of formula I wherein, R, R, R, X and Y are described hereinabove. The combination of the AChE inhibitor and mGluR2 antagonist is useful for treating and/or preventing chronic neurological disorders. These disorders include Alzheimer's disease and mild cognitive impairment.