The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2007
Filed:
Jan. 24, 2005
Jeffrey Scott Albert, Wilmington, DE (US);
Peter Bernstein, Wilmington, DE (US);
Cyrus Ohnmacht, Jr., Wilmington, DE (US);
Keith Russell, Wilmington, DE (US);
Ashokkumar Bhikkappa Shenvi, Wilmington, DE (US);
Jeffrey Scott Albert, Wilmington, DE (US);
Peter Bernstein, Wilmington, DE (US);
Cyrus Ohnmacht, Jr., Wilmington, DE (US);
Keith Russell, Wilmington, DE (US);
Ashokkumar Bhikkappa Shenvi, Wilmington, DE (US);
Astrazeneca AB, Sodertalje, SE;
Abstract
The present application relates to internally cyclized naphthamide compounds of the formula Ia (wherein R, R, R, R, R, R, R, R, R, R, X, X, Y, Z, and n are as defined herein), which are useful, for example, for antagonizing the pharmacological actions of the neurokinin 1 (NK) receptor. In particular, these compounds are useful in the treatment of diseases in which Substance P is involved such as, for example, major depressive disorder, severe anxiety disorders, stress disorders, major depressive disorder with anxiety, eating disorders, bipolar disorder, substance use disorder, schizophrenic disorders, psychotic disorders, movement disorders, cognitive disorders, depression and/or anxiety, mania or hypomania, aggressive behaviour, obesity, rheumatoid arthritis, Alzheimer's disease, cancer, oedema, allergic rhinitis, inflammation, pain, gastrointestinal-hypermotility, Huntington's disease, chronic obstructive pulmonary disorder (COPD), hypertension, migraine, bladder hypermotility, and urticaria.