The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2007
Filed:
Sep. 07, 2005
Kenneth H. Grabstein, Mercer Island, WA (US);
Dean K. Pettit, Seattle, WA (US);
Raymond J. Paxton, Bellevue, WA (US);
Kenneth H. Grabstein, Mercer Island, WA (US);
Dean K. Pettit, Seattle, WA (US);
Raymond J. Paxton, Bellevue, WA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
Antagonists of mammalian interleukin-15 ('IL-15') are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease,