The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2007
Filed:
Sep. 30, 2005
Toshiki Murata, Nara-ken, JP;
Masaomi Umeda, Nara-ken, JP;
Sachiko Sakakibara, Nara-ken, JP;
Takashi Yoshiro, Nara-ken, JP;
Hiroki Sato, Nara-ken, JP;
Tsutomu Masuda, Nara-ken, JP;
Yuji Koriyama, Nara-ken, JP;
Mitsuiyuki Shimada, Meerbusch, DE;
Takuya Shintani, Kyoto-fu, JP;
Hiroshi Kadono, Hyogo-ken, JP;
Timothy B. Lowinger, Guilford, CT (US);
Karl B. Ziegelbauer, Haan, DE;
Kinji Fuchikami, Kyoto-fu, JP;
Hiroshi Komura, Nara-ken, JP;
Toshiki Murata, Nara-ken, JP;
Masaomi Umeda, Nara-ken, JP;
Sachiko Sakakibara, Nara-ken, JP;
Takashi Yoshiro, Nara-ken, JP;
Hiroki Sato, Nara-ken, JP;
Tsutomu Masuda, Nara-ken, JP;
Yuji Koriyama, Nara-ken, JP;
Mitsuiyuki Shimada, Meerbusch, DE;
Takuya Shintani, Kyoto-fu, JP;
Hiroshi Kadono, Hyogo-ken, JP;
Timothy B. Lowinger, Guilford, CT (US);
Karl B. Ziegelbauer, Haan, DE;
Kinji Fuchikami, Kyoto-fu, JP;
Hiroshi Komura, Nara-ken, JP;
Bayer Aktiengesellschaft, Leverkusen, DE;
Abstract
This invention is to provide a process for producing 2-amino-4,6-disubstituted nicotinic acid ester analogs and salts thereof, comprising the reaction shown by the following scheme. The ester analogs can be prepared in one pot, and in good yield by using tertiary alkyl cyanoacetate. Furthermore, the method is useful for preparing derivatives of various analogs of the ester, e.g. alkyl substituted and aryl substituted analogs.