The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2007
Filed:
Feb. 26, 2003
Alistair Lochead, Charenton le Pont, FR;
Alain Nedelec, Paris, FR;
Mourad Saady, Paris, FR;
Philippe Yaiche, Les Lilas, FR;
Alistair Lochead, Charenton le Pont, FR;
Alain Nedelec, Paris, FR;
Mourad Saady, Paris, FR;
Philippe Yaiche, Les Lilas, FR;
Sanofi-Aventis, Paris, FR;
Mitsubishi Pharma Corporation, Osaka, JP;
Abstract
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: (I) X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a Calkyl group and a hydrogen atom; Y represents a bond, an ethenylene group, an ethynylene group or a methylene group optionally substituted; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring optionally substituted; R2 represents a heterocyclic bicyclic rings, having 1–4 heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom and having 5–9 carbon atoms, of formula (II) R3 represents a hydrogen atom, a Calkyl group, a hydroxy group, a Calkoxy group or a halogen atom; R4 represents a hydrogen atom, a Calkyl group, a Calkoxy group or a halogen atom. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β or GSK3β and cdk5/p25, such as Alzheimer disease