The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2007
Filed:
Sep. 27, 2001
Rolf Berge, Norway, NO;
Karsten Kristiansen, Brody, DK;
Rolf Berge, Norway, NO;
Karsten Kristiansen, Brody, DK;
Thia Medica AS, Bergen, NO;
Abstract
The present invention relates to fatty acid analogues of the general formula (I): R-[x-CH]—COORwherein Ris; a C–Calkene with one or more double bonds and/or with one or more triple bonds, and/or a C–Calkyne, and/or a C–Calkyl, or a C–Calkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C–Calkoxy, C–Calkylthio, C–Cacyloxy or C–Calkyl, and wherein R2 represents hydrogen or C–Calkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR, and wherein Xindependent of each other are selected from the group comprising O, S, SO, SO, Se and CH, and with the proviso that at least one of the Xis not CH, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the (ω-1) carbon and the (ω-2) carbon, or between the (ω-2) carbon and the (ω-3) carbon, or between the (ω-3) carbon and the (ω-4) carbon, which can be used for the treatment and/or prevention of proliferative skin disorders. More specifically the invention relates to the inhibition of proliferation and/or differentiation of keratinocytes.