The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2007
Filed:
Apr. 14, 2000
James Mcshane, Wake Forest, NC (US);
Ray Wood, Raleigh, NC (US);
Sumio Watanabe, Aichi, JP;
Kiyoshi Iwamoto, Kagamihara, JP;
Katsumi Onai, Aichi, JP;
James McShane, Wake Forest, NC (US);
Ray Wood, Raleigh, NC (US);
Sumio Watanabe, Aichi, JP;
Kiyoshi Iwamoto, Kagamihara, JP;
Katsumi Onai, Aichi, JP;
Eisai Co., Ltd., Tokyo, JP;
Abstract
The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5° C.