The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 12, 2007

Filed:

May. 16, 2002
Applicants:

William Brown, Montreal, CA;

Christopher Walpole, Montreal, CA;

Niklas Plobeck, Södertälje, SE;

Inventors:

William Brown, Montreal, CA;

Christopher Walpole, Montreal, CA;

Niklas Plobeck, Södertälje, SE;

Assignee:

AstraZeneca AB, Sodertalje, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/495 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of general formula I Ris selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; Ris independently selected from ethyl and isopropyl; Ris independently selected from hydrogen and fluoro; Ris independently selected from —OH, —NHand —NHSOR; and Ris independently selected from hydrogen, —CFand C–Calkyl, or salts thereof or separate enantiomers and salts thereof; where each Rheteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C–Calkyl, NO, CF, C–Calkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as separate enantiomers of the compounds and salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.


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