The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2007
Filed:
Oct. 29, 2003
Walter Brieden, Brig, CH;
Josef Schröer, Susten, CH;
Christine Bernegger-egli, Münster, CH;
Eva Maria Urban, Visp, CH;
Michael Petersen, Visp, CH;
Jean-paul Roduit, Gröne, CH;
Katja Berchtold, Baltschieder, CH;
Holger Breitbach, Baltschieder, CH;
Walter Brieden, Brig, CH;
Josef Schröer, Susten, CH;
Christine Bernegger-Egli, Münster, CH;
Eva Maria Urban, Visp, CH;
Michael Petersen, Visp, CH;
Jean-Paul Roduit, Gröne, CH;
Katja Berchtold, Baltschieder, CH;
Holger Breitbach, Baltschieder, CH;
Lonza AG, Basel, CH;
Abstract
The invention relates to a novel process for the preparation of an aminoalcohol of the formula racemically or optically active, starting from 2-azabi-cyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)— or (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl) formamide of the formula to give (1S, 4R)- or (1R, 4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae and then cyclized to give the end compounds.