The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2007
Filed:
Dec. 20, 2002
George Bonneville, Baltimore, MD (US);
Greg Delahanty, Baltimore, MD (US);
Andrew J. Walz, Baltimore, MD (US);
George Bonneville, Baltimore, MD (US);
Greg Delahanty, Baltimore, MD (US);
Andrew J. Walz, Baltimore, MD (US);
MGI GP, Inc., Baltimore, MD (US);
Abstract
A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl derivatives comprises the steps of Formula (i) and Formula (ii); R—OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, Ris hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and Ris hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation