The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2007
Filed:
Dec. 05, 2003
Applicants:
Yunhai Cui, Heidelberg, DE;
Joerg Koenig, Griesheim, DE;
Dietrich Keppler, Dossenheim, DE;
Inventors:
Assignee:
Deutches Krebsforschungszentrum Stiftung des Offentlichen Rechts, Heidelberg, DE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/06 (2006.01); C12N 5/10 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.