The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2007
Filed:
Apr. 12, 2004
Andrea G. Cochran, San Francisco, CA (US);
Melissa A. Starovasnik, San Francisco, CA (US);
Nicholas Skelton, San Mateo, CA (US);
Andrea G. Cochran, San Francisco, CA (US);
Melissa A. Starovasnik, San Francisco, CA (US);
Nicholas Skelton, San Mateo, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention is directed to a model system for structure-activity relationship analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising peptides with a novel 'tryptophan zipper' scaffold (trpzip) that forms stable β-hairpin structure in solution. Methods of selecting and using such scaffold are provided herein, which are useful for mimicking native protein structures and interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.