The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2007
Filed:
Dec. 07, 1999
Applicants:
James Patrick Allison, Berkeley, CA (US);
Dana R. Leach, Albany, CA (US);
Matthew E. Krummel, Berkeley, CA (US);
Inventors:
James Patrick Allison, Berkeley, CA (US);
Dana R. Leach, Albany, CA (US);
Matthew E. Krummel, Berkeley, CA (US);
Assignee:
The Regents of the University of California, Office of Technology Transfer, Oakland, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
Abstract
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.