The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 05, 2007

Filed:

May. 23, 2003
Applicants:

Wesley Peter Blackaby, Buckhurst Hill, GB;

Jose Luis Castro Pineiro, Bishops Stortford, GB;

Simon Charles Goodacre, Benington, GB;

David James Hallett, Watford, GB;

Alexander Charles Humphries, Stevenage, GB;

Philip Jones, Pomezia, IT;

Kevin John Merchant, Ware, GB;

Michael Reader, Bishops Stortford, GB;

Inventors:

Wesley Peter Blackaby, Buckhurst Hill, GB;

Jose Luis Castro Pineiro, Bishops Stortford, GB;

Simon Charles Goodacre, Benington, GB;

David James Hallett, Watford, GB;

Alexander Charles Humphries, Stevenage, GB;

Philip Jones, Pomezia, IT;

Kevin John Merchant, Ware, GB;

Michael Reader, Bishops Stortford, GB;

Assignee:

Merck Sharp & Dohme Ltd., Hoddesdon, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 31/506 (2006.01); C07D 544/294 (2006.01); C07D 546/121 (2006.01);
U.S. Cl.
CPC ...
Abstract

A class of 8-fluoroimidazo[1,2-α]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAreceptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.


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