The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2007
Filed:
Mar. 12, 2004
David G. Winkler, Seattle, WA (US);
John Latham, Seattle, WA (US);
John Skonier, Shoreline, WA (US);
Diana Shpektor, Bothell, WA (US);
Trenton Hayes, Seattle, WA (US);
James Geoghegan, Seattle, WA (US);
David G. Winkler, Seattle, WA (US);
John Latham, Seattle, WA (US);
John Skonier, Shoreline, WA (US);
Diana Shpektor, Bothell, WA (US);
Trenton Hayes, Seattle, WA (US);
James Geoghegan, Seattle, WA (US);
Celltech R&D, Inc., Bothell, WA (US);
Abstract
Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.