The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2007
Filed:
Oct. 30, 2002
Per Antonsson, Lund, SE;
Per Bjork, Helsingborg, SE;
Mikael Dohlsten, Lund, SE;
Terje Kalland, Arese, IT;
Lars Abrahmsen, Bromma, SE;
Johan Hansson, Lund, SE;
Göran Forsberg, Lund, SE;
Per Antonsson, Lund, SE;
Per Bjork, Helsingborg, SE;
Mikael Dohlsten, Lund, SE;
Terje Kalland, Arese, IT;
Lars Abrahmsen, Bromma, SE;
Johan Hansson, Lund, SE;
Göran Forsberg, Lund, SE;
Active Biotech A.B., Lund, SE;
Abstract
A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, preferably TCRVβ, and T cell activation have been replaced by another amino acid residue while retaining the ability to activate a subset of T cells. In preferred embodiment the modified superantigen is a chimer between at least two wild-type superantigens (SA I, SA II etc) characterized in that one or more amino acid residues in a region determining binding to TCR and T cell activation have been interchanged between various wild-type superantigens. A therapeutic method making use of modified/chimeric superantigens as defined in the preceding paragraphs. An antibody preparation in which the cysteine residues that provide for interchain disulfide bonds have been mutated so as to forbid interchain disulfide bridges, preferably to serine residues, for use as pharmaceutical.