The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2007
Filed:
Mar. 23, 2005
Michael A. Apicella, Solon, IA (US);
Melvin G. Sunshine, Iowa City, IA (US);
Na-gyong Lee, Incheon, KR;
Bradford W. Gibson, Berkeley, CA (US);
Michael A. Apicella, Solon, IA (US);
Melvin G. Sunshine, Iowa City, IA (US);
Na-Gyong Lee, Incheon, KR;
Bradford W. Gibson, Berkeley, CA (US);
University of Iowa Research Foundation, Iowa City, IA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional HtrB protein, resulting in a mutant that lacks one or more secondary acyl chains and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, or the endotoxin isolated therefrom, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.