The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2007
Filed:
Mar. 25, 2002
Franciscus Marinus Hendrikus DE Groot, Nijmegen, NL;
Patrick Henry Beusker, Nijmegen, NL;
Johannes Wilhelm Scheeren, Malden, NL;
Dick DE Vos, Oegstgeest, NL;
Leonardus Wilhelmus Adriaan Van Berkom, Oss, NL;
Guuske Frederike Busscher, Nijmegen, NL;
Antoinette Eugenie Seelen, Heerlen, NL;
Ralph Koekkoek, Beuningen, NL;
Carsten Albrecht, Oss, NL;
Franciscus Marinus Hendrikus De Groot, Nijmegen, NL;
Patrick Henry Beusker, Nijmegen, NL;
Johannes Wilhelm Scheeren, Malden, NL;
Dick De Vos, Oegstgeest, NL;
Leonardus Wilhelmus Adriaan Van Berkom, Oss, NL;
Guuske Frederike Busscher, Nijmegen, NL;
Antoinette Eugenie Seelen, Heerlen, NL;
Ralph Koekkoek, Beuningen, NL;
Carsten Albrecht, Oss, NL;
Syntarga B.V., Nijmegen, NL;
Abstract
This invention is directed to prodrugs that can be activated at the preferred site of action in order to selectively deliver the corresponding therapeutic parent drugs to target cells or to the target site. This invention will therefore primarily but not exclusively relate to tumor cells as target cells. More specifically the prodrugs are compounds of the formula V—(W)—(X)—A—Z, wherein: V is a specifier; (W)—(X)—A is an elongated self-elimination spacer system; W and X are each a 1,(4+2n) electronic cascade spacer, being the same or different; A is either a spacer group of formula (Y)wherein: Y is a 1,(4+2n) electronic cascade spacer, or a group of formula U being a cyclization elimination spacer; Z is a therapeutic drug; k, l and m are integers from 0 (included) to 5 (included); n is an integer of 0 (included) to 10 (included), with the provisos that: —when A is (Y): k+l+m≧1, and if k+l+m=1; —when A is U: k+l≧1.