The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2007
Filed:
Jun. 07, 1995
Dean Engelhardt, New York, NY (US);
Elazar Rabbani, New York, NY (US);
Stanley Kline, Brooklyn, NY (US);
Jannis G. Stavrianopoulos, New York, NY (US);
Dollie Kirtikar, Elmhurst, NY (US);
Dean Engelhardt, New York, NY (US);
Elazar Rabbani, New York, NY (US);
Stanley Kline, Brooklyn, NY (US);
Jannis G. Stavrianopoulos, New York, NY (US);
Dollie Kirtikar, Elmhurst, NY (US);
Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc., Farmingdale, NY (US);
Abstract
The present invention provides a nucleotide having the formula, wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to SM at a position independently selected from the 2', 3′, and 5′ positions of SM when the nucleotide is a ribonucleotide, and at a position independently selected from the 3′ and 5′ positions when the nucleotide is a deoxyribonucleotide. BASE is attached to the 1′ position of SM from the Nposition when BASE is a pyrimidine, or the Nposition when BASE is a purine or 7-deazapurine. Sig is a detectable moiety covalently attached to SM directly or through a linkage group. Also provided are an oligo- or polynucleotide comprising at least one such sugar moiety labeled nucleotide, and other compositions including those wherein a polypeptide is terminal ligated or attached to the oligo- or polynucleotide. The sugar moiety labeled nucleotide, and the oligo- or polynucleotides and other compositions comprising such nucleotides, are useful as diagnostic tools for detecting analytes and as therapeutic agents.