The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2007
Filed:
Nov. 21, 2001
Pravin T. P. Kaumaya, Westerville, OH (US);
Caroline C. Whitacre, Columbus, OH (US);
Mythily Srinivasan, Columbus, OH (US);
Pravin T. P. Kaumaya, Westerville, OH (US);
Caroline C. Whitacre, Columbus, OH (US);
Mythily Srinivasan, Columbus, OH (US);
The Ohio State University, Columbus, OH (US);
Abstract
Agents for blocking T cell-mediated immune reactions are provided. Such agents are peptides, referred to as 'CD28 peptide mimetics', of from 15 to 30 amino acids in length. The CD28 peptide mimetics comprise the hexapeptide motif 'MYPPPY', SEQ ID NO:or a retro-inverso isomer thereof. The CD28 peptide mimetics further comprise flanking sequence at the amino and carboxyl terminus of the hexapeptide motif. Methods for treating subjects with T cell mediated autoimmune diseases or disorders are also provided. Such methods comprise administering one or more of the CD28 peptide mimetics to a subject with such a disease or disorder.