The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 22, 2007

Filed:

Aug. 02, 2002
Applicants:

Oral Alpan, Rockville, MD (US);

Tirumalai Kamala, Rockville, MD (US);

Polly Matzinger, Bethesda, MD (US);

William Hugold Velander, Blacksburg, VA (US);

Inventors:

Oral Alpan, Rockville, MD (US);

Tirumalai Kamala, Rockville, MD (US);

Polly Matzinger, Bethesda, MD (US);

William Hugold Velander, Blacksburg, VA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12P 21/00 (2006.01); A01K 67/00 (2006.01); A01K 67/027 (2006.01); C12P 21/06 (2006.01); C12N 5/00 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.


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