The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2007
Filed:
Nov. 16, 2004
Christian Werner, Hannover, DE;
Frank Nerenz, Hannover, DE;
Andreas Kanschik-conradsen, Garbsen, DE;
Kalakota S. Reddy, Midland, MI (US);
Christian Werner, Hannover, DE;
Frank Nerenz, Hannover, DE;
Andreas Kanschik-Conradsen, Garbsen, DE;
Kalakota S. Reddy, Midland, MI (US);
Honeywell International Inc., Morristown, NJ (US);
Abstract
Provided are methods of producing phosphitylated compounds, including 3'-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula II wherein R, R, R, R, and Rare independently hydrogen, C–Calkyl, C–Ccycloalkyl, C–Caryl, C–Caralkyl, C–Cheteroalkyl, or C–Cheteroaryl, and at least one of R, R, R, R, and Ris not hydrogen; (2) zwitterionic amine complexes; and (3) combinations of two or more thereof, to produce a phosphitylated compound. Further provided are methods for purifying phosphitylated compounds comprising the steps of providing a phosphitylated compound in a solution solvent, contacting said phosphitylated compound with a precipitation solvent, and precipitating said phosphitylated compound.