The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2007
Filed:
Apr. 11, 2001
Marcello Allegretti, L'Aquila, IT;
Riccardo Bertini, L'Aquila, IT;
Cinzia Bizzarri, L'Aquila, IT;
Vilma Sabbatini, L'Aquila, IT;
Ginfranco Caselli, Milan, IT;
Maria Candida Cesta, L'Aquila, IT;
Janete Peloia Barroso Gandolfi, Legal Representative, Milan, IT;
Giulio Agostino Gandolfi, Legal Representative, Milan, IT;
Maria Carla Gandolfi, Legal Representative, Milan, IT;
Arrigo Aldo Gandolfi, Legal Representative, Saronno (VA), IT;
Francesco Colotta, L'Aquila, IT;
Marcello Allegretti, L'Aquila, IT;
Riccardo Bertini, L'Aquila, IT;
Cinzia Bizzarri, L'Aquila, IT;
Vilma Sabbatini, L'Aquila, IT;
Ginfranco Caselli, Milan, IT;
Maria Candida Cesta, L'Aquila, IT;
Janete Peloia Barroso Gandolfi, legal representative, Milan, IT;
Giulio Agostino Gandolfi, legal representative, Milan, IT;
Maria Carla Gandolfi, legal representative, Milan, IT;
Arrigo Aldo Gandolfi, legal representative, Saronno (VA), IT;
Francesco Colotta, L'Aquila, IT;
Dompe S.p.A., L'Aquila, IT;
Abstract
N-(2-aminoaryl-propionyl)-amides of formula (1) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of 2-(aminoaryl)-propionyl amides of formula (1) for use in the ihibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.