The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2007
Filed:
May. 31, 2005
Alphonse Garcia, Montrouge, FR;
Xavier Cayla, Rochecorbon, FR;
Angelita Rebollo, Paris, FR;
Veronica Ayllon, Alicante, ES;
Aarne Fleischer, Paris, FR;
Alphonse Garcia, Montrouge, FR;
Xavier Cayla, Rochecorbon, FR;
Angelita Rebollo, Paris, FR;
Veronica Ayllon, Alicante, ES;
Aarne Fleischer, Paris, FR;
Institut Pasteur, Paris, FR;
Consejo Superior de Investigaciones Cientificas, Madrid, ES;
Centre National de la Recherche Scientifque, Paris, FR;
Abstract
A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type by: (a) culturing cells of the particular cell-type under non apoptotic conditions and culturing cells of the particular cell-type under apoptotic conditions, and (b) determining subcellular localization of the cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of the cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that the cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in the particular cell-type.