The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2007
Filed:
Oct. 23, 2002
John E. Thompson, Waterloo, CA;
Catherine Taylor, Waterloo, CA;
Dominic Cliche, Kitchener, CA;
Charles Dinarello, Boulder, CO (US);
Leonid Reznikov, Aurora, CO (US);
Benjamin Pomerantz, University City, MO (US);
John E. Thompson, Waterloo, CA;
Catherine Taylor, Waterloo, CA;
Dominic Cliche, Kitchener, CA;
Charles Dinarello, Boulder, CO (US);
Leonid Reznikov, Aurora, CO (US);
Benjamin Pomerantz, University City, MO (US);
Senesco Technologies, Inc., New Brunswick, NJ (US);
Abstract
The present invention provides methods of identifying an incidence of ischemia in mammalian tissue, particularly mammalian heart tissue. Further, a method of reducing apoptosis in mammalian tissue, preferably heart tissue, is provided. These methods involve measuring and comparing the gene expression levels of both apoptosis-specific eIF-5A and proliferating eIF-5A and correlating an incidence of ischemia when the expression level of apoptosis-specific eIF-5a is higher than proliferating eIF-5A. In the method of reducing apoptosis in mammalian tissue, there is provided an agent that inhibits expression of apoptosis-specific eIF-5A. Preferred agents are antisense oligonucleotides to human apoptosis-specific eIF-5A.