The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2007
Filed:
Jan. 20, 2004
Shunji Kamiyama, Kobe, JP;
Kazuto Yoshida, Ibo-gun, JP;
Yasuo Chikusa, Himeji, JP;
Jun Matsumoto, Kakogawa, JP;
Keisuke Matsuyama, Kobe, JP;
Shunji Kamiyama, Kobe, JP;
Kazuto Yoshida, Ibo-gun, JP;
Yasuo Chikusa, Himeji, JP;
Jun Matsumoto, Kakogawa, JP;
Keisuke Matsuyama, Kobe, JP;
Nagase & Co., Ltd., Osaka-shi, JP;
Abstract
The present invention provides a method for producing optically active flurbiprofen. The method of the present invention includes mixing racemic flurbiprofen and (S)- or (R)-3-methyl-2-phenylbutylamine in an organic solvent to produce a diastereomeric salt; and treating the diastereomeric salt with an acid in a second solvent. In the method of the present invention, flurbiprofen having a desired absolute configuration can be obtained very efficiently without repeating the procedure for optical resolution a plurality of times.