The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2007
Filed:
Jan. 27, 2005
Ester Fride, Efrat, IL;
Aviva Breuer, Jerusalem, IL;
Lumir Hanus, Jerusalem, IL;
Susanna Tchilibon, Jerusalem, IL;
Michal Horowitz, Jerusalem, IL;
Raphael Mechoulam, Jerusalem, IL;
Aaron Garzon, Rehovot, IL;
Ester Fride, Efrat, IL;
Aviva Breuer, Jerusalem, IL;
Lumir Hanus, Jerusalem, IL;
Susanna Tchilibon, Jerusalem, IL;
Michal Horowitz, Jerusalem, IL;
Raphael Mechoulam, Jerusalem, IL;
Aaron Garzon, Rehovot, IL;
Abstract
The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds efficiently to CB2 but do not bind to CB1. The compounds show no activity in behavioral tests in mice which together have been shown to be specific for tetrahydrocannabinol (THC)- type activity in the central nervous system mediated by CB1 but reduce blood pressure, block intestinal motility, and elicit anti-inflammatory and peripheral analgetic activity. The invention also relates to methods of treating, preventing, or managing hypertension, inflammation, pain, gastrointestinal diseases, autoimmune diseases, and tumors with the compounds of the invention.