The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2007
Filed:
Nov. 22, 2005
Ashim K. Mitra, Overland Park, KS (US);
Soumyajit Majumdar, Oxford, MS (US);
Ritesh Jain, Kansas City, MO (US);
Yasser Nashed, Thousand Oaks, CA (US);
Ashim K. Mitra, Overland Park, KS (US);
Soumyajit Majumdar, Oxford, MS (US);
Ritesh Jain, Kansas City, MO (US);
Yasser Nashed, Thousand Oaks, CA (US);
The Curators of the University of Missouri, Columbia, MO (US);
Abstract
Dipeptide, and tripeptide and tetrapeptide ester derivatives of bioactive agents are provided wherein the parent agents are substrates effluxed by the P-gp transporter. The derivatives are useful in treating the same condition as the bioactive agent. Also disclosed is a method for preparing a bioactive agent for targeted delivery by nutrient or peptide transporters comprising linking the agent to one or more groups of the formula —X—Y-Z-Z'-R; wherein each X, Y, Z, and Z′ is independently Met, Val, Thr, Tyr, Trp, Ser, Ala or Gly; R is independently H or an amino-protecting group; n=1, and each, n′, or n″ is independently 0 or 1.