The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2007
Filed:
Oct. 08, 2002
Malcom Anderson, Cheshire, GB;
Nicholas John Keen, Cheshire, GB;
Andrew David Bruce Pannifer, Cheshire, GB;
Richard Alexander Pauptit, Cheshire, GB;
Sian Rowsell, Cheshire, GB;
Malcom Anderson, Cheshire, GB;
Nicholas John Keen, Cheshire, GB;
Andrew David Bruce Pannifer, Cheshire, GB;
Richard Alexander Pauptit, Cheshire, GB;
Sian Rowsell, Cheshire, GB;
AstraZeneca AB, Sodertajle, SE;
Abstract
The invention provides crystalline forms of a polypeptide corresponding to the catalytic domain of Aurora kinase. The active site ATP binding pocket is defined by its amino acid residues and their atomic coordinates. This structure may be used to select or design chemical modulators of Aurora kinase, particularly Aurora inhibitors. These modulators may be used to treat diseases of cell proliferation, e.g. cancer.