The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2007
Filed:
Jan. 14, 2003
Alain F. Carpentier, Paris, FR;
Sophie Carpentier, Paris, FR;
Crystal M. Cunanan, Mission Viejo, CA (US);
Lillian J. Quintero, Chester, NY (US);
Michael N. Helmus, Worcester, MA (US);
Christine Loshbaugh, Irvine, CA (US);
H. Chris Sarner, Laguna Hills, CA (US);
Alain F. Carpentier, Paris, FR;
Sophie Carpentier, Paris, FR;
Crystal M. Cunanan, Mission Viejo, CA (US);
Lillian J. Quintero, Chester, NY (US);
Michael N. Helmus, Worcester, MA (US);
Christine Loshbaugh, Irvine, CA (US);
H. Chris Sarner, Laguna Hills, CA (US);
Edwards Lifesciences Corporation, Irvine, CA (US);
Abstract
A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50° C. for a time period of about 1 to 2 days. The method of treating a biological tissue may be utilized as a terminal sterilization step in a method for fixation of biological tissues, and bioprosthetic devices may be prepared by such fixation method. The fixation method may include the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to the terminal sterilization method. The aqueous sterilizing solution may be glutaraldehyde of about 0.625 weight percent buffered to a pH of about 7.4.