The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2007
Filed:
Feb. 07, 2005
Pan-chyr Yang, Taipei, TW;
Tse-ming Hong, Taipei, TW;
Jeremy J. W. Chen, Fongyuan, TW;
Cheng-chung Wu, Sanchong, TW;
Jin-yuan Shin, Taipei, TW;
Yi-jen Lee, Hou-Bi Tainan, TW;
Pan-Chyr Yang, Taipei, TW;
Tse-Ming Hong, Taipei, TW;
Jeremy J. W. Chen, Fongyuan, TW;
Cheng-Chung Wu, Sanchong, TW;
Jin-Yuan Shin, Taipei, TW;
Yi-Jen Lee, Hou-Bi Tainan, TW;
Advpharma Inc., , TW;
Abstract
This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.