The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2007
Filed:
Apr. 01, 2003
Domenico Regoli, Magog, CA;
Witold Neugebauer, Ottawa, CA;
Fernand Gobeil, Sherbrooke, CA;
Bichov Gabra, Fleurimont, CA;
Pierre Sirois, Orford, CA;
Domenico Regoli, Magog, CA;
Witold Neugebauer, Ottawa, CA;
Fernand Gobeil, Sherbrooke, CA;
Bichov Gabra, Fleurimont, CA;
Pierre Sirois, Orford, CA;
Universite De Sherbrooke, Sherbrooke, Quebec, CA;
Abstract
The present invention provides for a novel peptidic antagonist for the bradykinin B1 (BKB) receptor having very good to excellent affinities and selectivity for the BKBreceptor, in vitro and in vivo increase resistance to enzymatic degradation, superior pharmacokinetic properties, capability to significantly reduce microvascular leakage observed alongside diabetic-induced increase in vascular permeability, capability to significantly reduced the state of hyperalgesia alongside diabetes, capability to significantly reduce the infiltration of pro-inflammatory cells and general state of inflammation alongside allergic asthma.