The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2007
Filed:
Jun. 16, 2003
Bruce L. Rogers, Belmont, MA (US);
Jay P. Morgenstern, Boston, MA (US);
Julian F. Bond, Weymouth, MA (US);
Richard D. Garman, Arlington, MA (US);
Julia L. Greenstein, West Newton, MA (US);
Mei-chang Kuo, Palo Alto, CA (US);
Malcolm Morville, Shrewsbury, MA (US);
Bruce L. Rogers, Belmont, MA (US);
Jay P. Morgenstern, Boston, MA (US);
Julian F. Bond, Weymouth, MA (US);
Richard D. Garman, Arlington, MA (US);
Julia L. Greenstein, West Newton, MA (US);
Mei-Chang Kuo, Palo Alto, CA (US);
Malcolm Morville, Shrewsbury, MA (US);
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.