The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 01, 2007

Filed:

Feb. 07, 1994
Applicants:

Tetsuji Sudoh, Tokyo, JP;

Keiji Maekawa, Tokyo, JP;

Naoto Minamino, Miyazaki-gun, JP;

Kenji Kangawa, Miyazaki-gun, JP;

Hisayuki Matsuo, Kobe-shi, Hyogo, JP;

Atsushi Izumi, Tokyo, JP;

Mika Takashima, Tokyo, JP;

Inventors:

Tetsuji Sudoh, Tokyo, JP;

Keiji Maekawa, Tokyo, JP;

Naoto Minamino, Miyazaki-gun, JP;

Kenji Kangawa, Miyazaki-gun, JP;

Hisayuki Matsuo, Kobe-shi, Hyogo, JP;

Atsushi Izumi, Tokyo, JP;

Mika Takashima, Tokyo, JP;

Assignees:

Shionogi & Co., Ltd., Osaka, JP;

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.


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