The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2007
Filed:
Mar. 13, 2003
Raymond Antoine Stokbroekx, Beerse, BE;
Marc André Ceusters, Diest, BE;
Marcel Jozef Maria Van Der Aa, Turnhout, BE;
Marcel Gerebernus Maria Luyckx, Geel, BE;
Marc Willems, Vosselaar, BE;
Robert W. Tuman, Chalfont, PA (US);
Raymond Antoine Stokbroekx, Beerse, BE;
Marc André Ceusters, Diest, BE;
Marcel Jozef Maria Van der Aa, Turnhout, BE;
Marcel Gerebernus Maria Luyckx, Geel, BE;
Marc Willems, Vosselaar, BE;
Robert W. Tuman, Chalfont, PA (US);
Janssen Pharmaceutica N.V., , BE;
Abstract
This invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; Ris hydrogen, Calkyl, Calkyloxy, Calkylthio, amino, mono- or di(Calkyl)amino, Ar, ArNH—, Ccycloalkyl, hydroxymethyl or benzoyloxymethyl; Ris hydrogen, Calkyl, amino, aminocarbonyl, mono- or di(Calkyl)amino, Calkyloxycarbonyl, Calkylcarbonylamino, hydroxy or Calkyloxy; R, Rand Rare each independently selected from hydrogen, halo, Calkyl, Calkyloxy, trifluoromethyl, nitro, amino, cyano, azido, CalkyloxyCalkyl, Calkylthio, Calkyloxycarbonyl or Het; is Ar, ArCH— or Het; Arand Aroptionally substituted phenyl; Hetand Hetare optionally substituted monocyclic heterocycles; having angiogenesis inhibiting activity; their preparation, compositions containing them and their use as a medicine.