The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2007
Filed:
Dec. 19, 2003
Wenyan Wang, Edison, NJ (US);
Hung V. Le, Rockaway, NJ (US);
Jian-jun Liu, Parlin, NJ (US);
Vincent S. Madison, Mountain Lakes, NJ (US);
Winifred W. Prosise, Ramsey, NJ (US);
Shahriar Shane Taremi, Upper Montclair, NJ (US);
LI Xiao, Woodbridge, NJ (US);
Jun Zou, Cranbury, NJ (US);
Wenyan Wang, Edison, NJ (US);
Hung V. Le, Rockaway, NJ (US);
Jian-Jun Liu, Parlin, NJ (US);
Vincent S. Madison, Mountain Lakes, NJ (US);
Winifred W. Prosise, Ramsey, NJ (US);
Shahriar Shane Taremi, Upper Montclair, NJ (US);
Li Xiao, Woodbridge, NJ (US);
Jun Zou, Cranbury, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.