The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2007
Filed:
Oct. 28, 2003
George Kukolj, Mont-Royal, CA;
Lisette Lagacé, Lorraine, CA;
Martin Marquis, Laval, CA;
Daniel Lamarre, Terrebonne, CA;
Arnim Pause, Montreal, CA;
George Kukolj, Mont-Royal, CA;
Lisette Lagacé, Lorraine, CA;
Martin Marquis, Laval, CA;
Daniel Lamarre, Terrebonne, CA;
Arnim Pause, Montreal, CA;
Boehringer Ingelheim International GmbH, Ingelheim, DE;
Abstract
An inhibitor-resistant HCV NS3 protease is provided which is useful to screen for compounds having therapeutic value against drug resistant HCV strains. In particular, the inhibitor-resistant HCV NS3 protease comprises an amino acid sequence which is mutated in the substrate binding pocket thereof rendering the protease resistant to inhibitor. In a specific aspect of the present invention, at least one of the amino acids at position 155, 156 and 168 of the HCV NS3 protease is mutated to yield an inhibitor-resistant protease.