The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2007
Filed:
May. 22, 1998
Brian R. Murphy, Bethesda, MD (US);
Peter L. Collins, Rockville, MD (US);
Anna P. Durbin, Germantown, MD (US);
Mario H. Skiadopoulos, Potomac, MD (US);
Tao Tao, Bethesda, MD (US);
Brian R. Murphy, Bethesda, MD (US);
Peter L. Collins, Rockville, MD (US);
Anna P. Durbin, Germantown, MD (US);
Mario H. Skiadopoulos, Potomac, MD (US);
Tao Tao, Bethesda, MD (US);
Abstract
Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a nucleoprotein (N), phosphoprotein (P), and a large (L) polymerase protein to produce isolated infectious PIV particles. The recombinant PIV genome and antigenome can be modified to produce desired changes, for example to incorporate attenuating mutations from biologically derived PIV mutants or to create chimeric PIV clones, to generate attenuated, immunogenic viruses for vaccine use.