The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2007
Filed:
Sep. 27, 2001
Mark W. Bitensky, Waban, MA (US);
Tatsuro Yoshida, Newton, MA (US);
Michael G. Frank, East Lansing, MI (US);
Christopher V Gabel, Sumerville, MA (US);
Jure Derganc, Ljubljana, SI;
Mark W. Bitensky, Waban, MA (US);
Tatsuro Yoshida, Newton, MA (US);
Michael G. Frank, East Lansing, MI (US);
Christopher V Gabel, Sumerville, MA (US);
Jure Derganc, Ljubljana, SI;
The Trustees of Boston University, Boston, MA (US);
Abstract
A cellular diagnostic array has been developed that provides accurate and reproducible measurements of the physical parameters of individual cells en masse, including cell membrane surface area, cell volume, and excess membrane. Three differing patterns are employed. In the first design, a gradient array having rectangular shaped channels is used to capture cells and readily show the ratio of volume to surface area for the captured cell. The second silicone rubber array provided by the present invention employs an array of wedge shaped pipettes, each of which captures an individual cell. The position of the cell within a wedge is enough to rapidly determine the cell's actual surface area and volume. A third type of cellular diagnostic array according to the present invention employs an array of channels designed to deform a cell to study how well the cell responds to repeated deformations.