The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2007
Filed:
Jan. 29, 2003
Jean-paul René Marie André Bosmans, Rijkevorsel, BE;
Ann Louise Gabriëlle Meulemans, Mol, BE;
Michel Anna Jozef DE Cleyn, Merkplas, BE;
Henricus Jacobus Maria Gijsen, Breda, NL;
Jean-Paul René Marie André Bosmans, Rijkevorsel, BE;
Ann Louise Gabriëlle Meulemans, Mol, BE;
Michel Anna Jozef De Cleyn, Merkplas, BE;
Henricus Jacobus Maria Gijsen, Breda, NL;
Janssen Pharmaceutica, N.V., Beerse, BE;
Abstract
The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, —R—R— is a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with Calkyl or hydroxy; Ris hydrogen or halo; Ris hydrogen or Calkyl; Ris hydrogen or Calkyl; L is Ccycloalkyl, oxoCcycloalkyl, Calkenyl, or L is a radical of formula -Alk-R—, Alk-X—R, -Alk-Y—C(═O)—R, or -Alk-Y—C(═O)—NRRwherein each Alk is Calkanediyl; and Ris hydrogen, amino, cyano, Calkylsulfonylamino, Ccycloalkyl, oxoCcycloalkyl, aryl or a heterocyclic ringsystem; Ris hydrogen, Calkyl, hydroxyCalkyl, Ccycloalkyl, aryl or a heterocyclic ringsystem; X is O, S, SOor NR; said Rbeing hydrogen or Calkyl; Ris hydrogen, Calkyl, Ccycloalkyl, Calkyloxy, hydroxy or aryl; Y is a direct bond or NR; said Rbeing hydrogen, or Calkyl; Rand Reach independently are hydrogen, Calkyl, Ccycloalkyl, or Rand Rcombined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating or preventing gastrointestinal disorders.