The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2007
Filed:
Nov. 22, 2001
Applicant:
Reginald M. Gorczynski, Willowdale, CA;
Inventor:
Reginald M. Gorczynski, Willowdale, CA;
Assignee:
Trillium Therapeutics Inc., Toronto, Ontario, CA;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/435 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
Abstract
A truncated form of the full-length, immunosuppression-inducing molecule, CD200, CD200, was expressed in CHO cells and the transduced cells used to produce mAbs to CD200. These mAbs detect simultaneous expression of full-length CD200 and CD200in LPS-stimulated dendritic cells (DCs). Moreover, CHO cells and DCs expressing CD200as well as soluble CD200are able to inhibit suppression of mixed leucocyte reactions in vitro which follows addition of the soluble form of CD200 (CD200:Fc) in culture, demonstrating that CD200is a physiological antagonist of CD200.