The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2007
Filed:
Jul. 29, 2004
Michael Breslav, Maple Glen, PA (US);
Bruce Harris, Lansdowne, PA (US);
Birdella Kenney, North Wales, PA (US);
Thomas Maier, Stockach, DE;
Armin Roessler, Tengen, DE;
Frank Villani, Perkasie, PA (US);
Ulrich Weigl, Hilzingen, DE;
Fan Zhang-plasket, Willow Grove, PA (US);
Hua Zhong, Maple Glen, PA (US);
Michael Breslav, Maple Glen, PA (US);
Bruce Harris, Lansdowne, PA (US);
Birdella Kenney, North Wales, PA (US);
Thomas Maier, Stockach, DE;
Armin Roessler, Tengen, DE;
Frank Villani, Perkasie, PA (US);
Ulrich Weigl, Hilzingen, DE;
Fan Zhang-Plasket, Willow Grove, PA (US);
Hua Zhong, Maple Glen, PA (US);
Ortho-McNeil Pharmaceutical Inc., Raritan, NJ (US);
Abstract
The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.