The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2007
Filed:
Jan. 10, 2002
Gerrit Klaerner, Campbell, CA (US);
Didier Benoit, San Jose, CA (US);
Dominique Charmot, Los Gatos, CA (US);
Srinivas Nomula, San Jose, CA (US);
Marcelo Eduardo Piotti, San Jose, CA (US);
Laura T. Mazzola, Redwood City, CA (US);
Gerrit Klaerner, Campbell, CA (US);
Didier Benoit, San Jose, CA (US);
Dominique Charmot, Los Gatos, CA (US);
Srinivas Nomula, San Jose, CA (US);
Marcelo Eduardo Piotti, San Jose, CA (US);
Laura T. Mazzola, Redwood City, CA (US);
Symyx Technologies, Inc., Santa Clara, CA (US);
Abstract
Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.