The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 10, 2007

Filed:

Mar. 25, 2004
Applicants:

Bishwajit Nag, Union City, CA (US);

Debendranath Dey, Fremont, CA (US);

Satyanarayana Medicherla, Cupertino, CA (US);

Partha Neogi, Fremont, CA (US);

Inventors:

Bishwajit Nag, Union City, CA (US);

Debendranath Dey, Fremont, CA (US);

Satyanarayana Medicherla, Cupertino, CA (US);

Partha Neogi, Fremont, CA (US);

Assignee:

Theracos, Inc., Sunnyvale, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/41 (2006.01); C07D 277/60 (2006.01);
U.S. Cl.
CPC ...
Abstract

Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.


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