The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2007
Filed:
Nov. 08, 2000
Alessandro Sette, La Jolla, CA (US);
Federico Gaeta, San Rafael, CA (US);
Howard M. Grey, La Jolla, CA (US);
John Sidney, San Diego, CA (US);
Jeffery L. Alexander, San Diego, CA (US);
Alessandro Sette, La Jolla, CA (US);
Federico Gaeta, San Rafael, CA (US);
Howard M. Grey, La Jolla, CA (US);
John Sidney, San Diego, CA (US);
Jeffery L. Alexander, San Diego, CA (US);
Pharmexa Inc., San Diego, CA (US);
Abstract
The present invention provides compositions and methods of inhibiting or inducing activation of T cells in a patient. The methods comprise administering a therapeutically effective dose of pharmaceutical compositions comprising a pharmaceutically acceptable carrier and peptides of between about 4 and about 20 residues, that bind antigen binding sites on MHC molecules encoded by substantially all alleles of a DR locus. These peptides are referred to as pan DR binding peptides. The pan DR binding peptides can be used to inhibit immune responses associated with immunopathologies, such as autoimmunity, allograft rejection and allergic responses. The peptides can also be used in combination with CTL peptides to enhance a CTL response.