The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2007
Filed:
Aug. 18, 2004
Paulus Wohlfart, Bensheim, DE;
Teri Suzuki, Tucson, AZ (US);
Ramalinga M. Dharanipragada, Belle Meade, NJ (US);
Alena Safarova, Tucson, AZ (US);
Armin Walser, Tucson, AZ (US);
Hartmut Strobel, Liederbach, DE;
Paulus Wohlfart, Bensheim, DE;
Teri Suzuki, Tucson, AZ (US);
Ramalinga M. Dharanipragada, Belle Meade, NJ (US);
Alena Safarova, Tucson, AZ (US);
Armin Walser, Tucson, AZ (US);
Hartmut Strobel, Liederbach, DE;
Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, DE;
Abstract
A method of stimulating the expression of endothelial NO-synthase in a mammal, which method comprises administering a physiologically active amount of 4-fluoro-N-indan- 2-yl benzamide according to the formula (I) to the said mammal. Compound (I) can be used for the therapy and prophylaxis of cardiovascular diseases like stable and unstable angina pectoris, Prinzmetal angina (spasm), acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease PAOD, atherosclerosis, restenosis, endothelial damage after PTCA, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, and the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives, the therapy and prophylaxis of diabetes and diabetes complications (nephropathy, retinopathy), angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, restricted memory performance or a restricted ability to learn.