The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2007
Filed:
Apr. 12, 2005
Applicants:
Jianxin Gu, River Edge, NJ (US);
Mark E. Ruppen, Garnerville, NY (US);
Panolil Raveendranath, Monroe, NY (US);
Warren Chew, Outremont, CA;
Chia-cheng Shaw, St. Laurent, CA;
Inventors:
Jianxin Gu, River Edge, NJ (US);
Mark E. Ruppen, Garnerville, NY (US);
Panolil Raveendranath, Monroe, NY (US);
Warren Chew, Outremont, CA;
Chia-Cheng Shaw, St. Laurent, CA;
Assignee:
Wyeth, Madison, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/18 (2006.01); C07D 498/22 (2006.01); A61K 31/435 (2006.01); A61K 31/436 (2006.01);
U.S. Cl.
CPC ...
Abstract
Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.