The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2007
Filed:
Dec. 09, 1999
R. Martin Emanuele, Alpharetta, GA (US);
Konstantin G. Kousoulas, Baton Rouge, LA (US);
Hameedsulthan S. Allaudeen, Durham, NC (US);
R. Martin Emanuele, Alpharetta, GA (US);
Konstantin G. Kousoulas, Baton Rouge, LA (US);
Hameedsulthan S. Allaudeen, Durham, NC (US);
Other;
Abstract
The present invention relates to compositions and methods for delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a delivery composition comprising an administerable admixture of an effective amount of a nucleic acid sequence and an effective amount of a surface active nonionic block copolymer having the following general formula:HO(CHO)(CHO)(CHO)Hwherein a is an integer such that the hydrophobe represented by (CHO) has a molecular weight between approximately 750 and approximately 15,000, preferably between approximately 2250 and approximately 15,000, more preferably between approximately 3250 and approximately 15,000, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 1% to approximately 50% by weight of the compound, preferably approximately 5% to approximately 25%.