The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2007
Filed:
May. 08, 2002
Norbert Lamping, Hannover, DE;
Hans-dieter Zucht, Hannover, DE;
Harmut Selle, Hannover, DE;
Michael Jürgens, Hannover, DE;
Gabriele Heine, Hannover, DE;
Rüdiger Hess, Hannover, DE;
Norbert Lamping, Hannover, DE;
Hans-Dieter Zucht, Hannover, DE;
Harmut Selle, Hannover, DE;
Michael Jürgens, Hannover, DE;
Gabriele Heine, Hannover, DE;
Rüdiger Hess, Hannover, DE;
Biovision AG, , DE;
Abstract
The invention relates to defined peptides and the quantitative determination thereof in body fluids of patients suffering from progredient chronic dementia, in relation to the concentration of said peptides in a control group. The inventive peptides come from a protein precursor having the corresponding gene, are processed in a specific manner, and are optionally post-translationally modified, especially phosphorylized. An increase in the concentrations of these peptides or the corresponding non-processed protein indicates progredient chronic dementia. Progredient chronic dementia is detected by identifying the peptides and/or the protein individually or in combinations. The invention also relates to the use of said peptides for controlling the course of progredient chronic dementia and for the prognosis of progredient chronic dementia, especially for complementing or replacing mini-mental scores, and for developing therapeutic agents to combat progredient chronic dementia such as Alzheimer's disease.