The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2007
Filed:
Jun. 12, 2003
Hong Cai, Los Alamos, NM (US);
Peter M Goodwin, Los Alamos, NM (US);
Richard A. Keller, Los Alamos, NM (US);
Rhiannon L. Nolan, Santa Fe, NM (US);
Hong Cai, Los Alamos, NM (US);
Peter M Goodwin, Los Alamos, NM (US);
Richard A. Keller, Los Alamos, NM (US);
Rhiannon L. Nolan, Santa Fe, NM (US);
Los Alamos National Security, LLC, Los Alamos, MN (US);
Abstract
Background luminescence is reduced from a solution containing unbound luminescent probes, each having a first molecule that attaches to a target molecule and having an attached luminescent moiety, and luminescent probe/target adducts. Quenching capture reagent molecules are formed that are capable of forming an adduct with the unbound luminescent probes and having an attached quencher material effective to quench luminescence of the luminescent moiety. The quencher material of the capture reagent molecules is added to a solution of the luminescent probe/target adducts and binds in a proximity to the luminescent moiety of the unbound luminescent probes to quench luminescence from the luminescent moiety when the luminescent moiety is exposed to exciting illumination. The quencher capture reagent does not bind to probe molecules that are bound to target molecules and the probe/target adduct emission is not quenched.